Post-doc in Membrane Protein Design, Molecular Biophysics, and Chemical Biology

Company: CHARMM-GUI
Location: San Diego
Posted on: May 9, 2025

Job Description:

CHARMM is a versatile program for atomic-level simulation of many-particle systems, particularly macromolecules of biological interest. - M. Karplus
Post-doc in Membrane Protein Design, Molecular Biophysics, and Chemical Biology
Date
2021-03-04
Location
San Diego, CA; Scripps Research
Description
Mravic Lab @ The Scripps Research Institute, La Jolla, CA campus
Title
Post-doc in Membrane Protein Design, Molecular Biophysics, and Chemical Biology
Contact
Apply to Dr. Mravic at mmravic@scripps.edu with a cover letter, CV with publication list, and contact information for 3 references. Unpublished first-author manuscripts can be included for review. More info on lab website:
Research Areas

• Design and characterization of synthetic membrane proteins: Using protein design to hypothesize and test chemical rules and features for protein structure or function in lipid. Focuses on creating simplified membrane protein models to understand disease mechanisms, improve in silico prediction, and enable bioengineering applications.
  
• Design of chemical biology tools: Developing computational algorithms to design hydrophobic mini-proteins and peptides that insert into lipid bilayers and target membrane proteins at their transmembrane regions. These tools help manipulate protein states and study disease mechanisms for therapeutic insights.
  
  The lab employs computational methods like bioinformatics, modeling, and molecular dynamics, alongside experimental techniques such as NMR, X-ray crystallography, lipid cubic phase crystallography, chemical synthesis, bioconjugation, and cellular assays. Candidates with additional skills like cryo-EM are encouraged to apply.
  Basic Qualifications
  

• 
  
• Molecular cloning, mammalian cell culture, protein expression & purification
  
• Biophysical and structural characterization of proteins (FRET, NMR, Cryo-EM, X-ray)
  
• Computational biology and programming (Python, Perl, Bash, C++)
  
• Proven research productivity with peer-reviewed publications
  
  Preferred Qualifications
  
  • 
    
  • Experience with membrane protein expression, purification, and structural biology
    
  • Computational biophysics, high-performance computing, GPU acceleration
    
  • Proficiency with molecular modeling and simulation software
    
  • Skills in bioinformatics, statistics, clustering, machine learning
    
    How to Apply
    Send your application to Dr. Mravic at mmravic@scripps.edu with a cover letter, CV, publication list, and contact info for 3 references. Unpublished manuscripts are welcome. More info available on the lab website.
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Keywords: CHARMM-GUI, La Mirada , Post-doc in Membrane Protein Design, Molecular Biophysics, and Chemical Biology, Other , San Diego, California