Structural Biologist
Company: US Main
Location: San Diego
Posted on: May 6, 2025
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Job Description:
Eli Lilly and Company seeks a Structural Biologist (R5-R7) to
support structure-based drug discovery (SBDD)projects focused on G
protein-coupled receptors (GPCRs).
A variety of soft skills and experience may be required for the
following role Please ensure you check the overview below
carefully.
Perform structure determination and drug design for GPCR and
membrane protein targets as well as soluble protein targets.
Apply biochemical, biophysical, and computational techniques to
accelerate generation of high-quality reagents for X-ray
crystallography and cryogenic electron microscopy (cryo-EM)
studies.
Determine structures and co-complex structures of protein targets
for the design of small-molecule and antibody therapeutics.
Develop integrative approaches to SBDD incorporating data and input
from structural biology, biophysics, protein biochemistry, and
medicinal chemistry teams.
#LI-DNI Position requires a Ph.D.
in Structural Biology, Biophysics, Biochemistry, Chemistry, or a
related field, and 2 years of academic or employment experience
with GPCR biology, pharmacology, and structure-based research
studies of GPCRs.
Academic or employment experience must include a minimum of: 2
years of experience with protein engineering, protein biochemistry,
and protein structure determination by X-ray crystallography or
cryo-EM; 2 years of experience with construct design, molecular
cloning, and protein expression and purification; 2 years of
experience with chromatographic methods for isolating recombinant
proteins and HPLC/FPLC systems; 2 years of experience with
SDS-PAGE, Western blot, thermal shift assays, and ELISA; and 2
years of experience with computational tools for protein structure
determination and analysis, including CCP4, Phenix, COOT, PyMol,
and Chimera.
Part time telecommuting may be permitted.
Up to 10% domestic and international travel required.
#LI-DNI Job location: San Diego, CA.
RATE OF PAY: $168,709.00
- $178,709.00 per year.
To apply, please visit https://jobsearch.lilly.com/ and enter job
requisition number R-84158 when prompted.
Alternatively, please send your resume, cover letter, and a copy of
the ad to: Beth L.
Berry, Lilly Corporate Center, Indianapolis, IN 46285.
Keywords: US Main, La Mirada , Structural Biologist, Other , San Diego, California
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